3D kidney organoids for bench-to-bedside translation

3D Imaging Bone Quality: Bench to Bedside

Abstract Introduction Measuring the health of bone is important for understanding the pathogenesis, progression, diagnosis and treatment outcomes for fragility. At present the most common method for measuring bone health in a clinical setting is to assess skeletal mass. The current gold standard is dualenergy X-ray absorptiometry (DXA) which models bones as 2D objects and measures areal bone mi...

Stem Cell Therapy for Bronchopulmonary Dysplasia: Bench to Bedside Translation

Bronchopulmonary dysplasia (BPD), a chronic lung disease affecting very premature infants, is a major cause of mortality and long-term morbidities despite of current progress in neonatal intensive care medicine. Though there has not been any effective treatment or preventive strategy for BPD, recent stem cell research seems to support the assumption that stem cell therapy could be a promising a...

Dr. Herman Kabat: neuroscience in translation … from bench to bedside.

Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation

Pancreatic ductal adenocarcinoma (referred here as pancreatic cancer) is a lethal disease with the worst prognosis among all solid tumors. Surgical resection represents the only hope for cure but it is possible only in patients that present with local disease (about 20% of cases). Whether dismal prognosis of pancreatic cancer is a result of late diagnosis or early dissemination to distant organ...

Bench-to-bedside review: Glucose production from the kidney

Data obtained from net organ balance studies of glucose production lead to the classic view according to which glucose homeostasis is mainly ensured by the liver, and renal glucose production only plays a significant role during acidosis and prolonged starvation. Renal glucose release and uptake, as well as the participation of gluconeogenic substrates in renal gluconeogenesis, were recently re...